Nejati A, et al. - Researchers sought the efficacy of IN ketamine in acute pain management in the Emergency Department (ED) via performing a double blind randomized clinical trial on patients older than 15 years who needed digital nerve block (DNB); IN Ketamine (1 ml = 50 mg) or placebo (normal saline, 1 ml) 5 min before DNB was administered to participants randomly. Outcomes suggest a potential efficacy of IN ketamine in reducing pain in patients with acute pain, without adding significant side effects.