van der Nelson H, O’Brien S, Burnard S, et al. - In this randomized double‐blinded clinical trial, researchers compared intramuscular oxytocin, Syntometrine and carbetocin for prevention of postpartum hemorrhage after vaginal birth. They randomized 5,929 normotensive women having a singleton vaginal birth when birth was imminent. Participants taking additional uterotonics: 368 (19.5%) oxytocin, 298 (15.6%) Syntometrine and 364 (19.1%) carbetocin. Outcomes do not support the non inferiority of carbetocin to Syntometrine. Carbetocin does not differ significantly from oxytocin for use of additional uterotonics. Decreased use of additional uterotonics and need for non‐drug PPH treatments was noted in correlation with using Syntometrine compared with oxytocin. The disadvantage reported with using Syntometrine was raised maternal side effects.