Chauhan P, et al. - Whether intralesional measles, mumps, and rubella (MMR) vaccine has efficacy and safety in patients of molluscum contagiosum, was evaluated herein. Experts examined data from 22 patients, including 10 men and 12 women. Age of patients ranged from 6 years to 50 years with a mean of 19.72 ± 10.92. After 12 weeks, complete clearance of lesions was seen in 18 patients (81.8%), with 4 patients (18.18%) showing a partial response of more than 50%. Post‐inflammatory hyperpigmentation occurred only in one patient who had giant molluscum. None of the patients suffered any other adverse impact. Findings demonstrated not only the safety and effectiveness of MMR for lesions of molluscum contagiosum but also it affords an easy to administer, time‐saving, and inexpensive therapy for molluscum contagiosum.