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Intragastric infusion of the bitter tastant quinine suppresses hormone release and antral motility during the fasting state in healthy female volunteers

Neurogastroenterology & Motility Aug 10, 2017

Deloose E, et al. – Objectives of this study were to assess the effect of intragastric administration of the bitter tastant quinine–hydrochloride (QHCl) on motilin and ghrelin plasma levels and to examine the effect on interdigestive motility. The authors revealed that QHCl suppressed the increase of both motilin and ghrelin plasma levels. Furthermore, QHCl reduced the fluctuation of antral motility. They validated the potential of bitter taste receptors as targets for modifying interdigestive motility in man.
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