González IA, Bauer PS, Liu J, et al. - Since tumour budding (TB), desmoplastic reaction (DR) and intraepithelial tumour infiltrating lymphocytes (iTILs) are recently recognised prognostic factors in colorectal cancer (CRC). This study was sought to assess their significance and association with each other and their cumulative effect on survival. Between 2013 and 2016, researchers enrolled a sum of 372 stages I–III CRC cases. They distinguished low TB in 302 (81%) cases, immature/myxoid DR in 67 (18%) cases and iTILs in 130 (35.0%) cases. This research confirms the relationship of iTILs and DR as independent prognostic finding in CRC, and propose a prognostic model applying the combinations of iTILs with TB and stromal reaction in CRC.