Currin S, et al. - Via a retrospective, case-control study on 15 consecutive men with ISUP GG 2 and 3 (intermediate risk, Gleason score 7) prostate cancer (PCa) with prostatic intraductal carcinoma (IDC-P) diagnosed at radical prostatectomy, the researchers compared apparent diffusion coefficient (ADC) values and Prostate Imaging and Data Reporting System to determine if IDC-P alters the MRI appearance of PCa. No differences in age, prostate serum antigen, tumor size, or stage between groups were observed. Compared with tumors without IDC-P, ISUP GG 2 and 3 (intermediate risk, Gleason score 7) PCa with IDC-P had lower ADC with a similar percentage of Gleason pattern 4 and resemble ISUP GG 4 and 5 high-risk tumors on MRI with the former. Hence, among intermediate-risk prostate cancer, IDC-P lowered ADC values.