Jurgensmeier K, Jurgensmeier D, Kunz DE, et al. - A randomized controlled trial was designed to compare the efficacy of triamcinolone vs ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee. Researchers randomized a total of 110 patients (52 hips and 58 knees) with moderate to severe radiographic primary osteoarthritis of the hip or knee to receive an ultrasound-guided intra-articular injection of ketorolac or triamcinolone. Patient-reported outcome measures were obtained pre-injection and at 1 week, 1 month, and 3 months. It was reported that for primary hip and knee osteoarthritis, intra-articular ketorolac injections provide comparable improvement to triamcinolone. For conservative management of primary osteoarthritis, ketorolac is an additional low-cost option, and due to its different mechanism of action, it may not propagate additional cartilage damage or preclude from early surgical intervention if unsuccessful.