Di Berardino F, et al. - Herein, the authors intended to investigate the urinary levels of lactulose and mannitol (double sugar test) and the fecal calprotectin, both markers of altered intestinal permeability, in individuals with definite Meniere disease (MD) in an active and inactive stage. Only the symptomatic MD patients reported an altered intestinal permeability, according to the two assays. It was determined that the rationale for a potential connection between MD and intestinal permeability was forwarded. A possibility existed for implementing the double-sugar test and FC quantification, in the MD diagnostic workup.