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Intestinal cancer in patients with Crohn disease: A systematic review and meta‐analysis

Journal of Gastroenterology and Hepatology Oct 07, 2020

Uchino M, Ikeuchi H, Hata K, et al. - Given that while several guidelines for Crohn disease (CD) are recommended for surveillance colonoscopy, there is insufficient evidence to support the validity of this recommendation, researchers performed a systematic review and meta‐analysis investigating the incidence of intestinal cancer and a literature review to clarify the characteristic features of cancer in CD. Overall, 7,344 patients were involved in eight studies. Data reported that the standardized incidence ratios of colorectal cancer (CRC) and small bowel cancer (SBC) were 2.08 and 22.01, respectively. During a median follow‐up of 12.55 years, the prevalence of CRC and SBC was 57/7344 (0.77%) and 17/7344 (0.23%), respectively. While the authors were unable to make a recommendation for SBC surveillance, CRC cancer surveillance should be performed in patients with CD. However, according to geography or race, the characteristics of cancer can vary. They need to develop proper and efficient surveillance methods that are independently appropriate for the identification of these differences.

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