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Interstitial pneumonia with autoimmune features show better survival and less exacerbations compared to idiopathic pulmonary fibrosis

BMC Pulmonary Medicine Jul 12, 2019

Lim JU, et al. - Researchers compared patients with interstitial pneumonia with autoimmune features (IPAF) to patients with connective tissue disease related-interstitial lung disease (CTD-ILD) and patients with idiopathic pulmonary fibrosis (IPF) in terms of clinical features and clinical outcomes. They analyzed ILD patients from a single institution ILD cohort. Overall ILD patients were 305, of those, the classification of IPAF was met by 54 (17.7%) patients, IPF was present in 175 (57.4%) patients, and 76 (24.9%) patients were diagnosed with CTD-ILD. Distinct clinical features were demonstrated by IPAF vs other ILD groups. Better survival and less episodes of exacerbation were seen in the IPAF group vs the IPF group. Significant links of age, forced vital capacity, ILD exacerbation, and ILD type were also reported in multivariate analysis for mortality.
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