Brown SAW, Padilla M, Mhango G, et al. - By analyzing data from all participants in the National Lung Cancer Trial excluding those with preexisting interstitial lung disease or prevalent lung cancers, researchers investigated the link between interstitial lung abnormalities and risk of lung cancer. They carried out a primary analysis with patients who underwent low-dose computed tomography, and a confirmatory analysis including those undergoing chest radiography. Using Poisson and Cox regression, they compared participants with and without interstitial lung abnormalities with regard to lung cancer incidence and mortality, respectively. In this study, asymptomatic interstitial lung abnormalities were identified as an independent risk factor for lung cancer which can be included into risk score models. A higher incidence of lung cancer was seen in those with interstitial lung abnormalities, which was maintained upon adjusted analyses. These patients also had higher lung cancer-specific mortality.