Vasan RS, et al. - Among Framingham Study participants (n=6203, mean age 50±15 years, 54% women), researchers examined the link between arterial stiffness (assessed by carotid-femoral pulse wave velocity, mean arterial pressure, central pulse pressure) and the prevalence and incidence of target organ damage [TOD](defined as albuminuria and/or echocardiographic left ventricular hypertrophy). They also assessed the association between presence of TOD and incident cardiovascular disease (CVD) in multivariable Cox regression models without and with adjustment for arterial stiffness measures. A 33% greater hazard of incident CVD was reported in relation to the presence of TOD, this was reduced upon adjustment for baseline arterial stiffness measures by 5–21%. Findings revealed a link between elevated arterial stiffness and presence of TOD. The links of TOD with incident CVD could be partially mediated by elevated arterial stiffness. The burden of TOD and, in turn, clinical CVD, could be attenuated by mitigating arterial stiffness.