Borg R, et al. - In a large population (198,346 individuals) in primary care, researchers investigated the association of fasting plasma glucose with HbA_1c measurements, as well as how anemia or chronic kidney disease impacts the interpretation of HbA_1c values. They noted that the fasting plasma glucose-HbA_1c relationship was similar to the regression described in the A1c-Derived Average Glucose (ADAG) study, which was based on average capillary and interstitial glucose. No significant impact of mild to moderate anemia and CKD was revealed on the interpretation of HbA_1cas a marker of retrograde glycemia. Thereby justifying the use of HbA_1c without adjustment in primary care.