Grzanka R, et al. - Researchers investigated a possible link between the acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria (CSU) patients. They determined serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6), key markers of acute phase response and of D-dimer, a marker of fibrin turnover in 58 CSU patients evaluated with the urticaria activity score (UAS) and the controls. They found correlation between markers of inflammation (IL-6 and CRP) and of fibrinolysis (D-dimer) in CSU, suggesting a possible cross-talk between inflammation and coagulation/fibrinolysis. Its possible involvement in the pathogenesis of the disease as well as its possible relation to higher risks of cardiovascular diseases in CSU patients was also suggested.