Yan Y, Jiang L, Fang J, et al. - The independent predictors of interpectoral lymph nodes (IPNs) metastasis were investigated in invasive breast cancer (IBC). In addition, some evidence for rational decision-making was reported. Researchers retrospectively reviewed data from 214 IBC patients who underwent treatment with modified radical mastectomy (MRM) + IPN dissection or biopsy in Ningbo Medical Center Lihuili Hospital. In overall population, IPN occurrence rate was 75.2%. Involvement of ALN was the only independent predictor associated with the occurrence of IPN by multivariate logistic regression analysis. Patients with pN0/N1 breast cancer had relatively low rate of IPN metastasis suggesting that IPN dissection can be safely omitted in patients with low tumor burden in axillary lymph nodes (pN0/N1), when MRM even breast conservation surgery is conducted.