Lai AYT, et al. - In order to contrast the interobserver agreement among whole-body CT (WB-CT) and whole-body MRI (WB-MRI, recommended by the International Myeloma Working Group for all patients with asymptomatic myeloma and solitary plasmacytoma) in the diagnosis of multiple myeloma, consecutive subjects with recently diagnosed myeloma imaged with WB-MRI and WB-CT were prospectively reviewed by the researchers. Among WB-MRI and WB-CT, no marked difference in overall observer score was noted. Interobserver agreement for WB-MRI was higher to WB-CT overall and for each region, with no overlap in whole-skeleton confidence periods, for expert observers whereas for inexperienced observers, however, there was a trend for a more reliable interobserver score for the entire skeleton on WB-MRI, the confidence intervals were seen overlapping. Hence, for experienced observers, WB-MRI granted the best interobserver agreement which was better than WB-CT. Although the overall burden was alike across both modalities, individuals with lower disease burdens where MRI could be advantageous were not covered in this series.