Intermittent vs continuous neuromuscular blockade during target temperature management after cardiac arrest: A nationwide observational study
Journal of Critical Care Jan 18, 2021
Takiguchi T, Ohbe H, Nakajima M, et al. - Researchers performed this retrospective cohort analysis to clarify if intermittent or continuous neuromuscular-blocking agents (NMBAs) would be suitable during target temperature management (TTM) following cardiac arrest. The Japanese Diagnosis Procedure Combination inpatient database was used. A comparison was conducted between the propensity-score-matched intermittent and continuous NMBA groups with respect to in-hospital mortality. In terms of mortality reduction in the overall population undergoing TTM for cardiac arrest, findings did not indicate that intermittent NMBAs may be inferior to continuous NMBAs. However, experts suggested that for providing mortality reduction in elderly patients, continuous NMBAs may be inferior to intermittent NMBAs.
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