Caballero MT, et al. - The target of researchers was to delineate risk factors associated with severe hypoxemia (O₂ sat ≤87%) in infants and children younger than 2 years hospitalized with single pathogen HRV infection. The enrollment consisted of children <2 years old between 2011 and 2013 in Argentina, with the inclusion of all children with respiratory signs and O₂ sat <93% on admission. HRV was detected as a single pathogen in 347 (6.92%) subjects. It was discovered that traditional risk factors for severe bronchiolitis did not exert an impact on the severity of illness. Analysis of targeted interventions against IL-13 was required in order to decrease the severity of HRV illness in infancy and early childhood.