van den Bent MJ, et al. - The use of radiotherapy with concurrent and adjuvant temozolomide in adults with non-co-deleted anaplastic gliomas was evaluated in this phase 3, randomised, open-label intergroup study. In patients with newly diagnosed non-co-deleted anaplastic glioma, adjuvant temozolomide chemotherapy was correlated with a significant survival benefit. Further analysis of the role of concurrent temozolomide treatment and molecular factors was required.