Michels L, Villanueva J, O'Gorman R, et al. - Researchers sought to determine differences in interictal cerebral blood flow (CBF) between patients with episodic migraine (EM) with or without aura and healthy controls (HC). Seventeen EM (mean age 32.7 ± 9.9, 13 females) and 19 HC (mean age 31.0 ± 9.3, 11 females) underwent interictal CBF assessment using 2D pseudo-continuous ASL-MRI on a 3 Tesla Philips scanner (University Hospital Zurich, Switzerland). Findings revealed CBF changes in the interictal state in correlation to extrastriate brain regions probably involved in cortical spreading depression. ASL-MRI is supported to be a sensitive method to recognize local neuro-functional abnormalities in CBF in patients with EM in the interictal state.