Martínez-planas A, Baquero-artigao F, Santiago B, et al. - Researchers conducted the study for analyzing the performance of interferon-gamma release assays (IGRAs) in the differential diagnosis between Mycobacterium avium complex (MAC) and tuberculosis (TB) in children affected with subacute/chronic submandibular/cervical lymphadenitis. The sample consisted of 78 patients with MAC and 34 with TB lymphadenitis. In contrast to the tuberculin skin test, IGRAs have high specificity, negative predictive value and positive predictive value for TB lymphadenitis in children with subacute/chronic lymphadenopathy, and can thus help distinguish between TB and MAC disease. As a result, IGRAs can help in the diagnosis of children with lymphadenopathy, especially when culture- and PCR-results are negative.