Ashraf M, Sampani K, Rageh A, et al. - In this cross-sectional observational study involving 225 patients (352 eyes) with type 1 or 2 diabetes who had undergone imaging between February 15, 2016, and December 31, 2019, researchers sought to assess the correlation of diabetic retinopathy (DR) lesion distribution with optical coherence tomography angiography (OCTA) metrics and DR severity. Findings indicate that central retinal vessel density was correlated with DR severity in eyes without, but not with, PPL. Such results indicate a potential need to stratify future OCTA studies of eyes with DR by the presence or absence of PPL. Assessment of global retinal nonperfusion using widefield angiography can improve the ability to assess DR severity and risk of DR worsening over time if DR onset and worsening are correlated with the location of retinal nonperfusion.