Shen Y, et al. - Given a strong recommendation of low tidal volume for acute respiratory distress syndrome (ARDS), researchers examined whether low tidal volume interacts with the severity of ARDS. They performed secondary analysis from a randomized controlled trial and included 836 ARDS patients (345 in the high PaO₂/FiO₂ (P/F) subgroup [> 150 mmHg] and 491 in the low P/F subgroup [≤ 150 mmHg]). As per findings, low tidal volume ventilation significantly interacts with oxygenation in patients with ARDS. Compared to the traditional tidal volume group, the high P/F subgroup showed significantly lower mortality of patients with low tidal volume [41/183 (22.4%) vs 64/162 (39.5%)] however, the same was not evident in the low P/F subgroup [95/256 (37.1%) vs 96/235 (40.8%)]. No clear findings regarding the benefits of low tidal volume ventilation in patients with severe ARDS were gained.