Luetragoon T, et al. - This study was performed on healthy individuals to explore the possible interactions among selected single nucleotide polymorphisms (SNPs) in genes related to systemic inflammation, smoking status, the levels of circulating immune response cells and plasma biomarkers of systemic inflammation. An association of smoking with systemic inflammation and increased levels of circulating immunosuppressive cells was noted. Among the smokers, an association was evident between the extent of these effects and SNPs. This finding may contribute to a better understanding of the genetic susceptibility of smoking-related disease and the variations observed in clinical outcomes.