Zhou Z, Xia C, Carcel C, et al. - In the BP arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED), researchers sought to analyze the differential impacts of early intensive vs guideline‐recommended blood pressure (BP) lowering between lacunar and non‐lacunar acute ischaemic stroke (AIS). In 1,632 candidates with definite or probable lacunar (n = 454 [27.8%]) or non‐lacunar AIS according to pre‐specified definitions based upon clinical and adjudicated imaging findings, mean BP changes over days 0–7 were plotted, and systolic BP differences by treatment between subgroups were calculated in generalized linear models. The treatment impact of early intensive vs guideline‐recommended BP reduction across lacunar and non‐lacunar AIS did not vary.