Davis JW, et al. - Via this network meta-analysis evaluating multicentre randomised controlled trials (RCTs) across various countries, researchers intended to estimate relative risk of statin-related musculoskeletal symptoms according to statin therapy intensity. To identify double-blinded RCTs examining the impact of statin treatment on lipids with at least 1000 participants and 2 years of intended treatment, they explored PubMed, Web of Science, Cochrane database and ClinicalTrials.gov. Muscle symptoms (any, myalgia and attrition because of muscle symptoms), rhabdomyolysis and increased creatine kinase (CK) (>10 × upper limit of normal) were set as outcomes. They finally analyzed 24 (n=152 461) eligible RCTs. As per network meta-analysis findings, high intensity statin therapy was associated with a significantly greater risk for any muscle problem, myalgia, attrition due to muscle problems and elevated CK, when compared with moderate intensity statin therapy. It was inferred that for about each 200 patients receiving high intensity statins, presence of myalgia or therapy cessation due to muscle problems may be seen in one additional patient, relative to moderate intensity therapy.