Nongpiur ME, Khor CC, Cheng CY, et al. - In this case-control study, researchers ascertained if the addition of primary angle closure glaucoma (PACG) associated genetic loci allows improved detection of PACG vs anterior segment parameters measured by imaging. A total of 388 PACG patients and 751 controls were accessible for assessment with both anterior segment optical coherence tomography and genetic information. According to results, the inclusion of genetic risk alleles (either individually or as a composite genetic risk score for 8 GWAS SNPs) in anterior chamber depth (ACD) only provided an improvement of +0.50% in the reclassification of PACG cases and controls beyond the discriminatory value of ACD. This improvement of +0.50% was not statistically significant. The authors concluded that the inclusion of genetic data in the context of anterior segment imaging parameters such as ACD, although significant on its own, provided only a marginal improvement of PACG detection.