Shaw E, et al. – This study assessed the impact of dietary fibre intake and non-steroidal anti-inflammatory drug (NSAID) use on the presence and type of colorectal polyps in a population screened for colorectal cancer. Findings demonstrated that intake of dietary fibre and NSAID use were associated with a decreased risk of having a high–risk adenomatous polyp (HRAP) at screening.

Methods

• Reseachers performed a cross-sectional study of 2548 individuals undergoing colonoscopy at the Forzani & MacPhail Colon Cancer Screening Centre (Calgary, Canada).
• They used the Diet History Questionnaire I or II and the Health and Lifestyle Questionnaire to assess dietary fibre intake and NSAID use.
• Colorectal outcomes were documented as a polyp or high-risk adenomatous polyp (HRAP; villous histology, high-grade dysplasia, ≥10 mm or ≥3 adenomas).
• Unconditional logistic regression was used to estimate crude and ORs and 95% CIs.

Results

• Findings showed that there were 1450 negative colonoscopies and 1098 patients with polyps, of which 189 patients had HRAPs.
• Researchers observed that total dietary fibre intake was associated with a decreased presence of HRAPs (OR=0.50, 95% CI: 0.29 to 0.86) when comparing the highest to lowest quartiles and was observed with both soluble (OR=0.51, 95% CI: 0.30 to 0.88) and insoluble (OR=0.51, 95% CI: 0.30 to 0.86) fibres.
• In addition, they noted an inverse association of ever use of NSAIDs with HRAPs (OR=0.65, 95% CI: 0.47 to 0.89), observed with monthly (OR=0.60, 95% CI: 0.37 to 0.95) and daily (OR=0.53, 95% CI: 0.32 to 0.86) use.