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Insulin resistance is associated with hirsutism in unselected reproductive-aged women

Clinical Endocrinology Mar 20, 2019

Song DK, et al. - In 2,139 reproductive-aged Korean women (15-39 years), researchers studied the distribution of the modified Ferriman-Gallwey (mFG) score and established its reference value for defining hirsutism [affects 5%-10% of reproductive-aged women worldwide] and analyzed its correlation with metabolic and reproductive traits. According to results, the mFG values of the 50th, 75th, 90th and 95th percentiles were 0, 1, 4 and 6, respectively. Multiple linear regression analysis showed that homoeostasis model assessment of insulin resistance (HOMA-IR) was positively linked to mFG score after adjustments for age, body mass index, total testosterone and the number of menses per year. According to findings, setting the 95th percentile of the mFG score as normal, the hirsutism reference value for reproductive-age Korean women was 6. Even after adjustment for biochemical hyperandrogenism, HOMA-IR was positively related to the mFG score.
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