Zhou Y, et al. - Researchers studied the correlation between insulin resistance and prognosis in a cohort of non-diabetic stroke patients with different estimated glomerular filtration rate (eGFR) strata. They included ischemic stroke patients without history of diabetes. Findings suggested an independent relationship between oral glucose tolerance test (OGTT)-derived estimate of insulin resistance and composite insulin sensitivity index (ISI), but not homeostasis model assessment of insulin resistance (HOMA-IR) and increased risks of 1-year mortality and poor functional outcome in non-diabetic ischemic stroke patients with different eGFR strata. They noted an association of HOMA-IR Q4 (insulin resistance) vs Q1–3 with increased 1-year mortality and poor functional outcome only in participants with an eGFR of ≥ 90 mL/minute/1.73 m².