Schrauben SJ, et al. - Researchers analyzed data for 1,883 participants in the Chronic Renal Insufficiency Cohort Study, to identify the issues related to insulin resistance and to describe the association of insulin resistance with progression of chronic kidney disease (CKD), cardiovascular events, and death in non-diabetics with CKD. They used the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to define insulin resistance. Using linear regression, they assessed links with insulin resistance. They used Cox proportional hazards models to determine the association of HOMA-IR, fasting glucose, hemoglobin A1c (HbA1c), and C-peptide with CKD progression, cardiovascular events, and all-cause mortality. Serum albumin, uric acid, and hemoglobin A1c were identified as potential determinants of HOMA-IR. Findings revealed no correlation between HOMA-IR and renal or cardiovascular events or all-cause mortality, supporting data that the link between insulin resistance and CKD-related outcomes is not consistent.