Laurenti MC, Man CD, Varghese RT, et al. - Since pulsatile insulin secretion is impaired in diseases like type 2 diabetes that are characterized by insulin resistance, researchers sought to explore the impacts of pulse characteristics on insulin action in humans, speculating that a decrease in pulse amplitude or frequency is correlated with impaired hepatic insulin action. They studied 29 nondiabetic individuals on two occasions. Overall, the data show that insulin pulse characteristics, viewed independently of other factors, do not correlate with measures of hepatic and peripheral insulin sensitivity in non-diabetic humans.