Wittenbecher C, et al. - Whether there is a prospective correlation of circulating insulin-like growth factor binding protein-2 (IGFBP-2) concentrations and of differential methylation in the IGFBP-2 gene with type 2 diabetes risk was investigated in a nested case-cohort (random subcohort, n=2,500, all incident type 2 diabetes cases, n=820) within the EPIC-Potsdam cohort (n=27,548). For DNA-methylation profiling, a nested 1:1 matched case-control sample (300 incident type 2 diabetes cases, 300 controls) was constructed. According to findings, high circulating IGFBP-2 concentration was found to have a type 2 diabetes-protective effect. Based on the observations, researchers also advised that type 2 diabetes might be predisposed by epigenetic silencing of the IGFBP-2 gene.