Escagedo PD, Deal CL, Dwyer AA, et al. - In this single-center retrospective study, researchers sought to evaluate the utility of serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) in identifying central precocious puberty (CPP) in girls aged 6–8 years. Baseline biochemical profiling and LHRH stimulation testing were performed on girls with confirmed CPP (n = 44) and isolated premature precocious adrenarche/precocious thelarche (PA/PT, n = 16). In clinical practice, IGF-1 standard deviation scores may be used to identify CPP in girls aged 6 to 8 years when baseline clinical and laboratory diagnostic criteria are inconclusive, potentially avoiding more time-consuming and costly procedures.