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Initiating buprenorphine treatment for opioid use disorder during short-term in-patient ‘detoxification’: A randomized clinical trial

Addiction Aug 28, 2019

Stein M, Herman D, Conti M, et al. - Researchers examined how starting buprenorphine during an opioid withdrawal program and linkage to office-based buprenorphine (LINK) following discharge would improve engagement with office-based buprenorphine and lower illicit opioid use during the subsequent 6 months vs standard withdrawal management (WM). They randomized 115 individuals with opioid use disorder (average age 32.4 years; 68.2% male; 79.1% white; reported using illicit opioids on 27.3 of the last 30 days) to WM (n = 59) vs LINK (n = 56) in this single-site randomized controlled trial. Among people with opioid use disorder, initiation of, and linkage to, office-based buprenorphine treatment post-discharge was related with a reduction in illicit opioid use and an increase in days of buprenorphine treatment for up to 6 months post-discharge vs an in-patient detoxification protocol.

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