Qian Z, et al. - In patients without human immunodeficiency virus (HIV) infection, experts examined the clinical outcomes achieved by using initial high-dose intravitreal ganciclovir injections to treat cytomegalovirus retinitis. Multiple intravitreal injections of ganciclovir in weekly intervals were received by 24 eyes (24 patients) with cytomegalovirus retinitis. Findings suggested that with an initial high dose of ganciclovir (6 mg) and continuous intravitreal injections of ganciclovir, a significant decrease in the cytomegalovirus load in HIV-negative patients with cytomegalovirus retinitis was seen.