Li W, Qiu C, Wang S, et al. - Researchers investigated how Glutathione S-transferase A3 (GSTA3), a member of the glutathione S-transferase family considered as an antioxidative protease, could impact cutaneous squamous cell carcinoma (cSCC). From 20 patients in plastic surgery department, cSCC tissues and para-carcinoma tissue specimens were collected. Experts treated A431 cells with GSTA3 transfection. Both cSCC tissues and A431 cells exhibited downregulation of GSTA3. By suppressing the TGF-β/Smad and HIF-1α signalings, GSTA3 could behave as an inhibitor of cSCC progression. Thus, GSTA3 may represent a prospective treatment target for cSCC.