Deng J, et al. - In epithelial ovarian cancer (EOC) chemoresistance, researchers determined the role of phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway as well as its link with epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) marker expression. Using immunofluorescence, western blot, and quantitative real-time PCR, they determined the expressions of EMT and CSC markers. According to the findings, activated PI3K/Akt/mTOR signaling triggered EMT and enhanced CSC marker expression, which were shown to be implicated in the chemoresistance of EOC in this study. In addition, EOC chemoresistance might be effectively reversed with BEZ235 (dactolisib) in combination with cisplatin. These findings are reported for the first time in this study.