Meiser A, et al. - Herein, isoflurane was compared with propofol and midazolam regarding sedation depth (per the Richmond Agitation-Sedation Scale), opioid consumption, lung function, and hemodynamics in ARDS patients treated with continuous lateral rotational therapy. Isoflurane sedation, compared with propofol or midazolam, led to significantly lower Richmond Agitation-Sedation Scale scores. Spontaneous breathing was possible in 90% of the subjects on isoflurane sedation compared with 16% of the subjects sedated with propofol or midazolam. The feasibility of isoflurane sedation using continuous lateral rotational therapy was supported.