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Infusion reactions associated with rituximab treatment for childhood-onset complicated nephrotic syndrome

Pediatric Nephrology May 25, 2018

Kamei K, et al. - Experts evaluated the infusion reactions (IR) incidence following rituximab treatment in complicated nephrotic syndrome in children. They reviewed the records of rituximab infusions in patients with complicated nephrotic syndrome between February 2006 and December 2014 at the National Center for Child Health and Development. Respiratory symptoms in patients with the complicated nephrotic syndrome were the major type of IR, mostly observed within 3 h of infusion. Compared to the patients with lymphoma, the incidence of IR was lower and its severity milder in patients with the complicated nephrotic syndrome.
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