Sun C, Zhang X, Lee WG, et al. - This study was attempted to assess whether resection of the IPFP affects clinical outcomes. Researchers performed a meta-analysis to distinguish relevant randomized controlled trials involving infrapatellar fat pad resection and infrapatellar fat pad preservation during total knee arthroplasty in electronic databases, including Web of Science, Embase, PubMed, Cochrane Controlled Trials Register, Cochrane Library, Highwire, CBM, CNKI, VIP, and Wanfang database, up to March 2020. The systematic review included nine randomized controlled trials, involving a total of 783 TKAs (722 patients). There is very difficult to demonstrate that one surgical technique of IPFP can definitively be considered superior over the other, based on the available level I evidence. Future adequately powered and better-designed randomized controlled trial (RCT) studies with long-term follow-up are needed to construct evidence-based guidelines regarding IPFP resection.