Wang C, Hu J, et al. - Researchers investigated how depressive symptoms and sleep disorders, in combination, affect cardiovascular disease (CVD) occurrence.

• The National Health and Nutritional Examination Survey (NHANES) database (2005– 2018) yielded data on 30,398 participants.

• CVD occurred in 11,544 (37.98%) participants but not in 18,854 (62.02%).

• Findings revealed an increased risk of CVD among patients in correlation with the presence of depressive symptoms and sleep disorders after adjusting all confounders.

• Risk of CVD appeared higher for patients with both depressive symptoms and sleep disorders relative to those without.

• Depression and sleep disorders may have a synergistic effect on the CVD occurrence, and the proportion of CVD caused by this interaction was 26.9%.