Lee JH, et al. - The prognostic value of symptom typicality was evaluated in patients who did not have obstructive coronary artery disease (CAD), as detected by coronary computed tomographic angiography (CCTA). Using the Diamond-Forrester criteria for angina pectoris, symptom typicality was classified as asymptomatic, nonanginal, atypical, and typical. In patients without prior history of CAD and without obstructive CAD (<50% CCTA stenosis), the risk of major adverse cardiac events (MACE) was determined using multivariable Cox proportional hazards models. In the CONFIRM registry, a higher rate of MACE was observed in patients who presented with concomitant typical angina and nonobstructive CAD, relative to asymptomatic patients with nonobstructive CAD. However, in patients with no CAD, the presence of typical angina did not appear to portend worse prognosis.