Maqsood S, Abdou Hannon A, Elalfy M, et al. - Researchers conducted this prospective noninterventional observational study to examine the impact of perfluorocarbon liquid (PFCL) use on retinal nerve-fiber layer (RNFL) thickness using spectral domain optical coherence tomography in eyes undergoing pars plana vitrectomy (PPV) with silicone-oil endotamponade with follow-up of 3 months. This investigation was carried out at the Research Institute of Ophthalmology, Egypt. Thirty patients who underwent PPV and silicone oil-based tamponade between April 2019 and September 2019 for either retinal detachment or diabetic retinopathy were recruited. The RNFL appears to, but not significantly, change postvitrectomy. For postvitrectomy patients with larger axial length and intraoperative PFCL use, careful examination and consistent follow-up are needed.