de Souza ABC, et al. - Since there exists no consensus if low free thyroxin (LFT) influences the rate of estimated glomerular filtration rate (eGFR) reduction in chronic kidney disease (CKD) and how the existence of proteinuria impacts renal dysfunction progression in hypothyroidism, so, researchers performed this study with CKD patients followed in general nephrology clinics, to evaluate thyroid status, proteinuria, and progression of eGFR by Modification of Diet in Renal Disease equation and CKD-EPI equation in this cohort. They estimated the link of LFT levels and the extent of proteinuria on the progression of eGFR. The study sample comprised 1,610 patients (64 ± 15 years, 46.8% men, 25.3% diabetic). Findings corroborated a faster rate of eGFR reduction in patients with proteinuria. However, no link was identified between LFT and rate of CKD progression despite the pathophysiological rationale that hypothyroidism can result in an increased rate of CKD progression. Based on these observations, experts concluded that prospective investigations are needed to be undertaken to assess the benefit of hypothyroidism treatment in CKD patients.