Duman EA, et al. – In this study, the researchers attempted to understand the relationship between early and recent life stress experiences, 5–hydroxytryptamine transporter–linked polymorphic region (5–HTTLPR) genotype, and solute carrier family 6 member 4 (SLC6A4) methylation. They found that both early and recent life stress alter DNA methylation as a function of 5–HTTLPR genotype. Some of these changes are also reflected in gene expression and cortisol response, differentially affecting individuals’ stress response in a manner that might confer susceptibility or resilience for psychopathology upon experiencing stressful life events.