da Silva TAL, de Medeiros DC, da Silva Cunha de Medeiros RC, et al. - Researchers conducted a double‐blind, crossover, randomized clinical trial investigating how curcumin supplementation affects the glycemic profile, inflammatory markers, and oxidative stress in HIV‐infected individuals under antiretroviral therapy. Participants were 20 individuals. Initially, the participants were arranged into experimental group (n = 10) and placebo group (n = 10) groups and were administered 1,000 mg curcumin/day or microcrystalline cellulose/day, respectively, during a 30‐day period and 12‐day washout. Subsequently, switching of the groups to follow the crossover design was done. In HIV‐infected individuals undergoing antiretroviral therapy and training, the glycemic, inflammatory, or oxidative stress profiles did not show any significant improvements in correlation with supplementation with curcumin. Although qualitative improvement was recorded in the mean serum fasting glucose levels and the homeostatic model assessment index in the CG, they emphasize practicing caution while interpreting this result since the recorded variation may represent acceptable fluctuation, in addition to the slight difference between the means, added to the great disparity noted in the standard deviation.