Baert T, et al. - Researchers explored the association of CA125, neutrophil to lymphocyte ratio (NLR) and thrombocytosis with serum markers of ovarian cancer patients, such as signaling proteins and cytokines. For clinical parameters (NLR, CA125, platelet count) and immune profile [IL-4 (interleukin), IL-10, IL-13, IL-17, transforming growth factor-β, Arginase-1, Interferon gamma), vascular endothelial growth factor (VEGF), galectin-1 and chemokine (C-C) motif ligand 2, serum samples from patients with high-grade serous ovarian cancer (HGSOC) were retrospectively assessed. Immune profile in HGSOC showed correlation to CA125, NLR and thrombocytosis at diagnosis, and demonstrated correlation with survival. High NLR showed a correlation with poor prognosis and an immunosuppressive profile. In patients with CA125 > 500 kU/L or thrombocytosis (>400 × 10⁹/l), increased IL-10 was detected.