Randeria SN, et al. - In a type 2 diabetes mellitus (T2DM) sample, researchers examined the correlation between abnormal blood clotting, clot ultrastructure, and the presence of a dysregulated inflammatory cytokine profile. The sample exhibited greatly dysregulated various biomarkers, across thromboelastography, cytokine and lipid groups. Compared to healthy sample, significantly more hypercoagulable coagulation profiles were detected in T2DM sample, with a matted and denser clot structure revealed on ultrastructural analysis. As concluded, the hypercoagulable state and vascular dysfunction in T2DM may in part be due to dysregulated circulating molecules. It might be important to look to new inflammatory and vascular biomarkers. Adoption of a personalized approach while planning therapy and following the patient health status after embarking on a treatment regime could be of great value.