Tamma R, et al. - Researchers examined 40 subjects to assess the significance of inflammatory cells infiltrate and angiogenesis in locally advanced and metastatic cholangiocarcinoma (CCA) cases. They noticed a vital incline in immune cell infiltrate composed of CD8⁺ and CD4⁺ lymphocytes, macrophages and mast cells in locally advanced CCA in comparison to metastatic cases. They also observed the relation between altered tumor microenvironment infiltrate and an increase in microvascular density (MVD) in localized CCA lesions. A negative correlation was also found between MVD and CD8⁺, CD4⁺ cells in subjects with localized CCA.